The number of replication origin sequences in the genome does not change during the lifespan of an organism, but the number of active origins does vary according to the developmental stage. In the ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

Figure 1: The DBF4 promoter locus contains a strong ori. Figure 2: Replication initiation at the DBF4 locus is largely confined to around 7 h after mitosis or 1 h after G1/S. Precise replication ...

To get insights into the regulation of replication initiation, we systematically mapped replication origins along 1% of the human genome in HeLa cells. We identified 283 origins, 10 times more than ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 40 (October 4, 2022), pp. 1-12 (12 pages) Eukaryotic chromosomes are organized into structural and ...

Today, we’re going to talk about genomes. Strictly speaking, genomes have two crucial functions: they must exist (to store genetic information and enable that information to be used by the cell), and ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease and ...

The research published in Nature on Dec. 25th, 2019, led by Dr. LI Guohong and Dr. ZHU Mingzhao from the Institute of Biophysics of the Chinese Academy of Sciences, has demonstrated that the histone ...

In the presence of some disruptive elements, cancer cells are unable to replicate its DNA optimally. While known to be linked to the increase in genetic mutations, the exact mechanism at work remained ...

A study by the Centre for Chromosome Biology at NUI Galway, Ireland, in partnership with the University of Zurich, has uncovered new insights into how the replication of DNA occurs which can be ...