Amid growing concerns about the poor design of animal experiments and its implications for the translatability of experimental results, Michael F. W. Festing thinks it's time we do something about it.

Microbial community samples can be efficiently surveyed in high throughput by sequencing markers such as the 16S ribosomal RNA gene. Often, a collection of samples is then selected for subsequent ...

The justification of sample size is one of the hardest sections of a proposal an IACUC (ethical review board) has to assess, yet is arguably one of the most important (1). This is a key opportunity ...

Sound experimental design is of vital importance when conducting any scientific experiment. Choices made at the design stage have the potential to drastically impact the results of any study. A strong ...

The landscape of gene editing applications is expanding quickly. More and more, researchers are faced with choosing the right tools and protocols for genome engineering, including overexpressing ...

The paper reviews questions of experimental design which arise in the analysis of categorized data. Particular reference is made to developments since the important paper of Cochran (1973) on ...

In this module, we will introduce the basic conceptual framework for experimental design and define the models that will allow us to answer meaningful questions about the differences between group ...

This story is part of Fast Company’s 2024 Innovation by Design Awards. Explore the full list of companies creating products, reimagining spaces, and working to design a better world. Read more about ...

Real-time polymerase chain reaction (PCR), also called quantitative PCR (qPCR), is one of the most powerful tools for nucleic acid analysis. However, inconsistencies in protocols, experimental design, ...